![]() ![]() Compared with the reference group with estimated baseline sodium excretion of 4 to 5.99 g per day (n = 14 156 6.3% participants with CV death, 4.6% with MI, 4.2% with stroke, and 3.8% admitted to hospital with CHF), higher baseline sodium excretion was associated with an increased risk of CV death (9.7% for 7-8 g/day hazard ratio, 1.53 95% CI, 1.26-1.86 and 11.2% for >8 g/day HR, 1.66 95% CI, 1.31-2.10), MI (6.8% HR, 1.48 95% CI, 1.11-1.98 for >8 g/day), stroke (6.6% HR, 1.48 95% CI, 1.09-2.01 for >8 g/day), and hospitalization for CHF (6.5% HR, 1.51 1.12-2.05 for >8 g/day). After a median follow-up of 56 months, the composite outcome occurred in 4729 (16.4%) participants, including 2057 CV deaths, 1412 with MI, 1282 with stroke, and 1213 with hospitalization for CHF. Results At baseline, the mean (SD) estimated 24-hour excretion for sodium was 4.77 g (1.61) and for potassium was 2.19 g (0.57). Main Outcome Measures CV death, myocardial infarction (MI), stroke, and hospitalization for congestive heart failure (CHF). ![]() We used Cox proportional hazards multivariable models to determine the association of urinary sodium and potassium with CV events and mortality. We used restricted cubic spline plots to describe the association between sodium and potassium excretion and CV events and mortality, and to identify reference categories for sodium and potassium excretion. We estimated 24-hour urinary sodium and potassium excretion from a morning fasting urine sample (Kawasaki formula). Objective To determine the association between estimated urinary sodium and potassium excretion (surrogates for intake) and CV events in patients with established CV disease or diabetes mellitus.ĭesign, Setting, and Patients Observational analyses of 2 cohorts (N = 28 880) included in the ONTARGET and TRANSCEND trials (November 2001-March 2008 from initial recruitment to final follow-up).
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